![]() The mediation through functional impairment may represent unmeasured proxy measures or point to a broader mechanism that impacts self-efficacy and agency. ![]() Conclusionsįindings did not support the proposed mediation hypotheses for coping, hope, and social support. The estimated proportion of effect mediated by functional impairment, and adjusted for confounders, was 31%. Functional impairment was the strongest mediator for focused psychosocial interventions on PTSD (mediation coefficient −0.087, standard error 0.040). We included 3,143 children from 11 studies (100% of data from included studies), of which 1,877 from six studies contributed to the mediation analysis. The hypotheses were tested by using individual participant data obtained from study authors of all the studies included in the systematic review. A systematic search on the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PubMed, PyscARTICLES, Web of Science, and the main local LMICs databases was conducted up to August 2018. Based on the simulated potential outcomes, the causal effects are computed for each subject. With this technique two fundamental concepts for future mediator-based bioprocesses will be evaluated: An all-in-one strategy where one cell is generating the mediators and the targeted product as well as a co-culture system, whereby one cell produces the mediators and a partner cell utilizes them for electro-respiration and product formation. 2 and 3 to simulate the potential mediator and outcome values for each subject. Based on an ecological resilience framework, we hypothesized that (a) coping, (b) hope, (c) social support, and (d) functional impairment mediate the relationship between intervention and outcome PTSD symptoms. The parametric simulation-based approach uses the sampling distributions of the estimated parameters from eqs. We conducted a preplanned mediation analysis using individual participant data from a dataset of 11 randomized controlled trials (RCTs) which compared focused psychosocial support interventions versus control conditions for children living in low- and middle-income countries (LMICs) affected by humanitarian crises. Identifying the potential pathways through which interventions work would potentially allow further strengthening of interventions by emphasizing specific components connected with such pathways. Research on psychosocial interventions has been focused on the effectiveness of psychosocial interventions on mental health outcomes, without exploring how interventions achieve beneficial effects.
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